Sigvaris 500 Series Natural Rubber Thigh High Stocking is ideal for patients with more serious indications or Long-Term Therapy.  Features include: Proven efficacy through numerous scientific studies; minimal fabric fatigue factor throughout the day; accommodates larger ankle circumference up to 18"(46cm) and calf circumference up to 27"(68cm); Open toe only.  Available with (not in 50-60mm/Hg) or without Beaded Siicone Grip-top at additional cost.   This product is often combined with the cotton Underliner (see options) for patient comfort.  Available in 30-40mm/Hg, 40-50mm/Hg (with or without Grip Top) and 50-60mm/Hg (only without Grip Top and Full Circumference).